Modeling Cellular Systems by Frederik Graw Franziska Matthäus & Jürgen Pahle

Author:Frederik Graw, Franziska Matthäus & Jürgen Pahle
Language: eng
Format: epub
Publisher: Springer International Publishing, Cham

1.1 Sampling from a Repertoire

What can be deduced from a sample of m cells taken from a repertoire of T cells if the total number of cells in the repertoire, S, is very large? Let us begin by describing the structure of the repertoire, which is divided into N subsets, called TCR clonotypes. Denote by the number of cells of a clonotype labelled i. The index i runs from 1 to N, and (see Fig. 1). Typically S is known, but N and with , are not.

Fig. 1The repertoire contains S cells, divided up into N TCR clonotypes. Here, cells are represented by circles, a TCR clonotype is the set of cells of one shade, and a random sample of cells is represented by those inside the black square

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